Charles Runels, MDEvery Man & Woman is Scuptor and Painter of the Body-Temple
| Testosterone and Auto-Immune Disease |
Do your own Google search of testosterone and any rheumatic disease and you will be amazed! The tragedy is that there are very few studies looking at replacing women with testosterone to help their disease because of the continued hesitancy to prescribe testosterone for women. The reason given, "we do not know the long term effects." So instead, most give drugs where we DO KNOW THAT THE LONG TERM EFFECTS CAN BE DANGEROUS and skip the testosterone where the over all effects seem to be wonderful (increased energy, decreased risk of cancer, better sex, increased clarity of thinking, weight loss. Here's a few research papers showing that testosterone helps defeat (cure and prevent) auto-immune disease:1 Klinefelter Syndrome
2. The Journal of Immunology, Vol 159, Issue 1 3-6, Copyright © 1997 by American Association of ImmunologistsCUTTING EDGE M Dalal, S Kim and RR Voskuhl Female SJL mice are more susceptible than male mice to experimental autoimmune encephalomyelitis (EAE) induced by myelin basic protein (MBP)-specific T lymphocytes. In the present study, we examined mechanisms involved in this gender-related difference in disease susceptibility. MBP-specific T lymphocytes derived from spleens of males during the effector phase of adoptive EAE produced significantly higher levels of IL-10, an anti-inflammatory cytokine in EAE. A protective effect of testosterone was then shown. Females implanted with dihydrotestosterone pellets demonstrated a significantly less severe course of EAE as compared with females implanted with placebo pellets. Finally, MBP-specific T lymphocytes derived from dihydrotestosterone-implanted females produced significantly higher levels of IL-10 than those from placebo. Together these data indicate that testosterone exerts a protective effect in EAE that is mediated at least in part by enhanced production of IL-10 by autoantigen-specific T lymphocytes. 3. The role of testosterone in Multiple Sclerosis 4. Sex hormone status of male patients with rheumatoid arthritis: evidence of low serum concentrations of testosterone at baseline and after human chorionic gonadotropin stimulation *Correspondence to Maurizio Cutolo, Via D. Chiodo 25 c/4, Genova 16136, Italy Abstract T D Spector, L A Perry, G Tubb, A J Silman and E C Huskisson Department of Rheumatology and Reproductive Endocrinology, St Bartholomew's Hospital, West Smithfield, London. The androgen status of 25 male patients with rheumatoid arthritis (RA) was assessed and compared with that of age matched controls with osteoarthritis (OA). Significantly reduced levels of serum free testosterone were found in the RA group. Within that group free testosterone was unrelated to all indices of disease activity measured, though it was strongly related to latex positivity. These results support the hypothesis that male sex hormones may have a protective role in RA, though prospective studies would be necessary to determine whether the relation was one of cause or effect. just do your own Google search of testosterone and any rheumatic disease and you will be amazed!
The tragedy is that there are very few studies looking at replacing women with testosterone to help their disease because of the continued hesitancy to prescribe testosterone for women. The reason given, "we do not know the long term effects." So instead, most give drugs where we DO KNOW THAT THE LONG TERM EFFECTS CAN BE DANGEROUS and skip the testosterone where the over all effects seem to be wonderful (increased energy, decreased risk of cancer, better sex, increased clarity of thinking.
Peace & Health,
Charles Runels, MD |