Uses of Platelet Derived Growth Factors (PDGF)

Platelet derived growth factors have been used for regnerating many different tissues. The growth factors activate stem cells to regenerate whatever tissue is near.

Here's how Platelet Derived Growth Factors are used in a product called Selphyl to regenerate the face.

Here are references about the use of PDGF:

• Increased blood flow from PDGF :the Biomedical Research Center and Department of Biological Sciences (C.-H.C., K.E.K., G.M.L., G.Y.K), Korea Advanced Institute of Science and Technology, Daejeon, Korea the Department of Medicine (J.B., H.-S.J., D.-K.K.), Samsung Medical Center and Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, Korea the Cardiovascular Research Institute, Comprehensive Cancer Center Department of Anatomy (P.B., F.B., D.M.M.), University of California, San Francisco the Department of Structural Analysis (N.M.), National Cardiovascular Center Research Institute, Suita, Osaka, Japan the Department of Anatomy (J.K.), College of Medicine, The Catholic University of Korea Seoul the Department of Physiology (B.H.J), College of Medicine, Chungnam National University Daejeon, Korea. Abstract Vascular enlargement is a characteristic feature of angiopoietin-1 (Ang1)-induced changes in adult blood vessels. However, it is unknown whether tissues having Ang1-mediated vascular enlargement have more blood flow or whether the enlargement is reversible. We have recently created a soluble, stable and potent Ang1 variant, COMP-Ang1. In the present study, we investigated the effects of varied dose and duration of COMP-Ang1 on vascular enlargement and blood flow in the tracheal microvasculature of adult mice and explored a possible mechanism of long-lasting vascular enlargement. We found that COMP-Ang1 administered by adenoviral vector induced long-lasting vascular enlargement and increased tracheal blood flow. In contrast, short-term administration of COMP-Ang1 recombinant protein induced transient vascular enlargement that spontaneously reversed within a month. In both cases, the vascular enlargement resulted from endothelial proliferation. The COMP-Ang1eCinduced vascular remodeling is mediated mainly through Tie2 activation. Sustained overexpression of Tie2 could participate in the maintenance of vascular changes. Together, our findings indicate that sustained treatment with COMP-Ang1 can produce long-lasting vascular enlargement and increased blood flow. Key Words: angiopoietin-1 COMP-Ang1 vascular enlargement blood flow
• PDGF increases growth of heart muscle: Growth-promoting effect of platelet-derived growth factor on rat cardiac myocytes Jie Liu, Li-ling Wu, , Li LI, Liang Zhang and Zong-En Song Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100083, China Received 12 May 2004; revised 18 October 2004; accepted 21 October 2004. Available online 9 December 2004.

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