Priapus Toxin™ & P-Shot® 100

Outline

  • The Priapus Toxin™ and P-Shot 100™ procedures
  • Scientific research regarding Priapus Toxin™ and P-Shot 100™
  • How to schedule an appointment

The Priapus Toxin™ and P-Shot 100™ Procedures

We have now been doing the P-Shot® procedure for over 10 years with much success and with a significant body of medical research supporting the procedure.

Over the past six years, a growing body of research (in animals and people) also supports the effectiveness and safety of injecting the corpus cavernosi of the penis with botulinum toxin.  In the latest randomized, double-blind, placebo-controlled prospective comparative study, the most effective and longest-lasting dose for improvement of erection firmness was 100 units of botulinum toxin in total (50 units into each corpus cavernosi). This dose showed effectiveness up to 6 months with maximal effect at 6 weeks.

The mechanism of action of botulinum toxin in the penis seems to be partly due to the relaxation of the smooth muscle of the arterioles, resulting in increased blood flow (and even in a small increase in length in one study). This increase in erection firmness by increasing arterial flow is exactly how Viagra and Tri-mix injections work. In two separate studies, the injection of botulinum toxin was helpful to some men (not all) for whom Viagra and Cialis had quit working.

Botulinum toxin (at doses much higher than 100 units) has been used for two decades for various problems with an extremely safe history.

The toxic LD50 dose for botulinum toxin for a 165-pound man is around 133 vials of 100 units each. We only use one vial of 100 units to do Priapus Toxin™ and P-Shot 100™. (Read, How many bottles of botulinum toxin does it take to kill someone” here).

The P-Shot 100™ procedure is a specific method of injecting blood-derived growth factors, including platelet-rich plasma (or platelet-rich fibrin matrix) and botulinum neurotoxin, to improve the health of the penis and enhance the size or function of the penis. The procedure includes patient selection, method of preparation of materials, method of injection, aftercare, and more.

I am now offering the P-Shot® (Priapus Shot®) procedure combined with 100 units of botulinum toxin–the combination of the two is called the P-Shot 100™ (Priapus Shot 100™) procedure.

Suppose someone wants botulinum toxin alone injected into the penis. In that case, we have the  Praipus Toxin™ procedure: a specific method of injecting the corpus cavernosi of the penis with botulinum neurotoxin (BoNT)– to improve penile tissue health and to enhance erectile function or penis size. The procedure includes patient selection, the method of preparation of the botulinum toxin the method of injection of the botulinum toxin, aftercare, and more.

As with all procedures, there can be no guarantee of the outcome (though I do guarantee not to keep your money if the procedure does not meet your expectations), and there can be complications (some unexpected and of unknown severity). Using botulinum toxin for ED is an off-label use for botulinum toxin not approved by the FDA--as are other common "off-label" uses of botulinum toxin. Some experts do not think toxins should be used for ED. Thankfully, we have 2 decades of use of toxins, with millions of doses per year, for many indications with an extremely high safety profile. The toxic LD50 for injecting cosmetic botulinum toxin (BoNT) iv for a 180-pound man is estimated to be around 150 to 200 Bottles of BoNT (or around 15,000 to 20,000 units); we only inject a total of 100 units of BoNT (one bottle) into the corpus carvernosi when we do the procedure (a smaller dose than what is often used to treat children with muscle spasm).
Guarantee: If you are not pleased with the results of your procedure for any reason or no reason at all, you can get a full refund for the procedure for up to 6 months.

Scientific Research 

  • Abdelrahman, Islam Fathy Soliman, Amr Abdel Raheem, Yaser Elkhiat, Abdelrahman A. Aburahma, Tarek Abdel-Raheem, and Hussein Ghanem. “Safety and Efficacy of Botulinum Neurotoxin in the Treatment of Erectile Dysfunction Refractory to Phosphodiesterase Inhibitors: Results of a Randomized Controlled Trial.” Andrology 10, no. 2 (2022): 254–61. https://doi.org/10.1111/andr.13104.
  • El-Shaer, Waleed, Hussein Ghanem, Tamer Diab, Ahmed Abo-Taleb, and Wael Kandeel. “Intra-Cavernous Injection of botulinum toxin (50 and 100 Units) for Treatment of Vasculogenic Erectile Dysfunction: Randomized Controlled Trial.” Andrology 9, no. 4 (2021): 1166–75. https://doi.org/10.1111/andr.13010.
  • Giuliano, Francois, Charles Joussain, and Pierre Denys. “Safety and Efficacy of Intracavernosal Injections of AbobotulinumtoxinA (Dysport®) as Add-on Therapy to Phosphosdiesterase Type 5 Inhibitors or Prostaglandin E1 for Erectile Dysfunction—Case Studies.” Toxins 11, no. 5 (May 21, 2019): 283. https://doi.org/10.3390/toxins11050283.
  • Habashy, Engy, and Tobias S. Köhler. “botulinum toxin for Erectile Dysfunction.” The Journal of Sexual Medicine 19, no. 7 (July 2022): 1061–63. https://doi.org/10.1016/j.jsxm.2022.03.216.
  • Naumann, Markus, and Joseph Jankovic. “Safety of Botulinum Toxin Type A: A Systematic Review and Meta-Analysis.” Current Medical Research and Opinion 20, no. 7 (July 2004): 981–90. https://doi.org/10.1185/030079904125003962.

    How to Schedule an Appointment

    If I speak with you by phone after you schedule your appointment or even during your initial visit, and we determine the procedure may not be the best choice for you, then you will receive a complete and cheerful refund. You will not even be charged for the consult. 
    — Charles Runels, MD

    P-Shot 100™ (Priapus Shot 100™)
    The P-Shot® procedure combined with the Bocox™ procedure (PRP combined with 100 Units of botulinum toxin).
    $2,787
    Schedule here<–Priapus Toxin™ Procedure: botulinum toxin 100 units alone (no P-Shot® added) injected into the penis (50 units into each corpus cavernosum)
    $1,797
    Schedule here<–

P-Shot® (Priapus Shot®) Procedure: The first procedure.
$1,800
Schedule here<–

Repeat P-Shot® (Priapus Shot®) Procedure: Repeat injection (recommended to wait 8-12 weeks for the full benefit of the first injection before determining if a second injection is needed)
$997
Schedule here<–