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Charles Runels, MD

 

SAM-e

 
Review Summary
As natural supplements grow in popularity, an increasing number of products have entered the market promising to help individuals cope with stress and ease symptoms of depression. Although prescription antidepressants have been a great help to many people struggling with depression and other mood disorders, natural supplements are becoming an increasingly accepted method of treating mild symptoms and managing stress.

Unlike well-known treatments like St. John’s Wort and Ginseng, SAMe is not an herb, but rather a chemical compound. It is still considered “natural” and is available without a prescription. We will take a close look at this compound in order to assess its benefits and determine possible alternatives.

 
Ingredients at a Glance
SAMe is an abbreviated marketing name for the chemical compound S-Adenosyl-Methionine.

 
Ingredients in Focus
S-Adenosyl-Methionine (SAMe) is a biological compound present in living cells. It was first discovered in 1952, but did not become popular as a dietary supplement until the late 1990’s. It was originally tested as a possible treatment for schizophrenia in Europe, and while it proved ineffective for that particular purpose, scientists did observe that it seemed to have some positive effect on depression if used regularly. In fact, it is currently regulated and prescribed like a drug in Europe. Some also believe that SAMe may help to prevent the onset of arthritis and even help to heal liver damage.

A healthy brain produces all of the SAMe it needs, but it is believed that the brains of depressed people may produce insufficient quantities of the compound. Scientists emphasize that supplemental SAMe will have no effect at all on healthy brains.

 
Lifestyle
Supplemental SAMe is likely to appeal to those who are experiencing mild and/or occasional depression and are interested in trying an all-natural formula. Of course, it goes without saying that those who believe that they may be suffering from depression or any other form of mental illness should seek advice from their doctor. However, many individuals have found relief from mild mood swings caused by PMS, menopause, and stress thanks to a dietary supplement.

Despite SAMe’s popularity, the effects of this compound are still not thoroughly understood, and some physicians believe that it may even exacerbate mood swings in some people. For this reason, consumers may want to look for a product that is gentler, and has been shown to be reliable for calming frazzled nerves.

 
Positives
• Available without a prescription
• Website posts some detailed information


 
Negatives
• Does not contain the natural form of the mineral lithium
• Website does not post testimonials
• No free trial sample available


 
Final Thoughts
Although SAMe has been shown to offer some relief from symptoms of mild depression, it is not a one-size-fits all treatment. A stressful job, PMS, menopause, and even the weather can cause some individuals to experience frustrating mood swings. Fortunately, the natural form of the mineral lithium has been shown to help calm these fluctuations and help individuals to resume a happy life on a more even keel. When combined with a natural absorption enhancer like Orotate, users generally find that just a small amount of natural lithium is enough to help them feel more like themselves.